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A Crack in Creation: Gene Editing and the…
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A Crack in Creation: Gene Editing and the Unthinkable Power to Control… (2017 original; edició 2017)

de Jennifer A. Doudna (Autor)

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267976,676 (4.17)13
Two Berkeley scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions.
Membre:Kamna.Tripathi
Títol:A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution
Autors:Jennifer A. Doudna (Autor)
Informació:Houghton Mifflin Harcourt (2017), 304 pages
Col·leccions:La teva biblioteca
Valoració:
Etiquetes:to-read

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A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution de Jennifer A. Doudna (2017)

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A very dry style delivering vast amounts of information, but it does highlight the complex steps and huge numbers of people involved in deliviering such a complex tool as CRISPR-Cas9. I know it's specifically about the science, but I did become concerned that she blithely enumerated the enormous amount of gene-editing that is carried out on animals in labs, but her ethical quandaries seemed to be only about using the techniques for gene-editing humans. ( )
  SChant | May 26, 2021 |
This is truly awful, a paper-thin overview of CRISPR technology. If you get your popular science from USA Today, you're well beyond the target audience. I wanted to learn some of the details of the science, some of the tradeoffs of the technology, and some of the dirt on the politics. There's none of that here. I suspect that the book was entirely written by Sternberg, and Doudna was too busy to contribute, because there's no evidence that she was seriously involved.

> There’s even a case to be made that this kind of genetic manipulation is better than breeding. Unlike micropigs, whose health is no different than their normal-size relatives, extensive inbreeding of dogs has had devastating health consequences. Labradors are prone to some thirty genetic conditions, 60 percent of golden retrievers succumb to cancer, beagles are commonly afflicted with epilepsy, and Cavalier King Charles spaniels suffer from seizures and persistent pain due to their deformed skulls.

> Cold-induced sweetening also causes potato chips to brown and take on a bitter taste, which results in a huge amount of waste; processing plants discard 15 percent of their potatoes a year for this reason. Using gene editing, researchers at Calyxt easily addressed the problem in Ranger Russet potatoes: they inactivated the single gene that produced glucose and fructose

> Huntington’s disease, in which the altered gene produces an abnormal protein that completely overrides the effect of the second, healthy copy of the gene. Since the mutated gene dominates the nonmutated gene, simple gene therapy—the addition of another normal copy of the gene using a retooled virus—would have no effect ( )
  breic | Feb 10, 2021 |
My personal opinion is that CRISPR will eventually be viewed by history through the same lenses through which penicillin & vaccines are now. This book allows you to go on the journey of it's groundbreaking discovery first-hand, which is not something that we normally used to get. Knowing the amount of caution, yet determination to have the ethical hurdles overcomed gives me hope that humanity won't find a way to "screw it up" like it did with nuclear energy. This isn't a book that will captivate you or blow you away, but it's a book that will end up aiding in reaching an outcome to the CRISPR debate the world is about to embark on. ( )
  parzivalTheVirtual | Mar 22, 2020 |
Super interesting subject, but not a good choice for an audiobook. Might come back to at some point to read in print.
  thegreatape | Jan 7, 2020 |
“A few people laughed... A few people cried... Most people were silent. I remembered the line from the Hindu scripture the Bhagavad Gita; Vishnu is trying to persuade the prince (Arjun) that he should do his duty and takes on his multi-armed form and says ‘Now I am become death, the destroyer of worlds’ “ – Robert Oppenheimer ; creator of the atomic bomb; The Manhattan Project 1945 .

These were his prophetic words of caution after the first successful detonation ; which echoes in Jennifer Doundna’s discovery of a gene editing tool CRISP-R / CAS 9 which has the potential to change humanity as we know it …forever ! Ethical ramifications take her down the winding road into a philosophical quagmire humans are yet to fathom .



( )
  Vik.Ram | May 5, 2019 |
Es mostren 1-5 de 9 (següent | mostra-les totes)
Some of the greatest benefactors of our species are not the recognized do-gooders but those paid to satisfy their curiosity: the scientists. Such pure and unsullied inquiry has yielded thousands of valuable byproducts, including antibiotics, vaccinations, X-rays and insulin therapy.

Jennifer Doudna and Samuel Sternberg’s “A Crack in Creation” describes another fortuitous discovery, a method that promises to revolutionize biotechnology by allowing us to change nearly any gene in any way in any species. The method is called CRISPR, pronounced like the useless compartment in your fridge. In terms of scientific impact, CRISPR is right up there beside the double helix (1953); the ability, developed in the 1970s, to determine the sequence of DNA segments; and the polymerase chain reaction, a 1980s invention that allows us to amplify specified sections of DNA. All three achievements were recognized with Nobel Prizes. CRISPR — developed largely by Doudna and her French colleague Emmanuelle Charpentier — also has a strong whiff of Nobel about it, for its medical and practical implications are immense.

The story of CRISPR is told with refreshing first-person directness in this book.
 

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Nom de l'autorCàrrecTipus d'autorObra?Estat
Doudna, Jennifer A.autor primaritotes les edicionsconfirmat
Sternberg, Samuel H.autor principaltotes les edicionsconfirmat
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Die Wissenschaft weiß nicht, was sie der Fantasie verdankt (Ralph Waldo Emerson)
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Für unsere Eltern, dorothy und Martin Doudna (J.A.D.)
und Susanne Nimmrichter und Robert Sternberg (S.H.S.)
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Two Berkeley scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions.

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